March 1, 2001International Journal of Molecular Medicine
Regulation of apoptosis by angiotensin II in the heart and lungs (Review)
Why the study?
Does angiotensin II regulate apoptosis in the heart and lungs?
Population
Cardiac myocytes, endothelial cells, and epithelial cells of the lung in culture, human pathological…
Design
Review
Authors
Discussion
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Member takes
Implication
Should not change RAS inhibitor use; leaves open paracrine apoptosis mechanisms in cardiac and pulmonary disease.
Structured PICO
Does angiotensin II regulate apoptosis in the heart and lungs?
P
Population
Cardiac myocytes, endothelial cells, and epithelial cells of the lung in culture, human pathological specimens, and animal models
I
Intervention
Angiotensin II / Renin-angiotensin system (RAS)
O
Outcome
Regulation of apoptosis
The renin-angiotensin system regulates apoptosis in the heart and lungs via paracrine and autocrine mechanisms, contributing to the pathogenesis of cardiovascular and pulmonary diseases.
Cite This Study
Filippatos et al. (2001) studied this question.