Why the study?
Does the WiCS-LV system provide a feasible and safe alternative for heart failure patients who failed conventional cardiac resynchronization therapy?
Does the WiCS-LV system provide a feasible and safe alternative for heart failure patients who failed conventional cardiac resynchronization therapy?
Wireless endocardial pacing with the WiCS-LV system is a feasible and promising alternative for heart failure patients who fail or are ineligible for conventional cardiac resynchronization therapy.
Answers are grounded in this paper and cite their sources.
May warrant evaluation in CRT nonresponders; leaves open confirmation of efficacy in randomized trials.
INTRODUCTION: There are several unsolved limitations in delivering cardiac resynchronization therapy. 30-40% of patients fail to have any clinical benefit after 6 months caused by different reasons. AREAS COVERED: Endocardial stimulation rather than conventional epicardial pacing has been shown to: be more physiologically, improve electrical stimulation of the left ventricular, give less dispersion of repolarisation and result in better resynchronization. The Wireless Cardiac Stimulation in Left Ventricle, WiCS-LV, system provides an option for wireless, left ventricular endocardial pacing triggered from a conventional right ventricular pacing spike from a co-implant. Expert commentary: The feasibility of the WiCS-LV system has been successfully demonstrated in a population of failed cardiac resynchronization patients, either failed implantation procedure of a conventional system, non-responder to conventional therapy or upgrade from pacemaker or defibrillator, where a conventional system was not an option. WiCS-LV is innovative technology with promising safety, performance and preliminary efficacy.
No takes yet. Share an insight, caveat, or question.
Seifert et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: