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March 18, 2010Coronary Artery Disease

The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease

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Why the study?

Does the ACE I allele prevent coronary artery disease in patients undergoing cardiac catheterization?

Population

300 patients who underwent cardiac catheterization

Comparison

Presence of the ACE I allele vs Presence of the ACE D allele

Design

Cross-sectional

Authors

AAAntoine AbcheeUniversity of BalamandMEMirvat El‐SibaiLebanese American UniversitySYSonia YouhannaKarolinska Institutet

Discussion

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Implication

Does not support ACE genotyping for CAD risk stratification; leaves open causal protection versus confounding in catheterization cohorts.

Structured PICO

Does the ACE I allele prevent coronary artery disease in patients undergoing cardiac catheterization?

P
Population
300 patients who underwent cardiac catheterization
I
Intervention
Presence of the ACE I allele
C
Comparator
Presence of the ACE D allele
O
Outcome
Coronary artery disease (defined as >70% stenosis in any vessel)surrogate

The ACE I allele is associated with a lower risk of significant coronary artery disease in patients undergoing cardiac catheterization.

Cite This Study

Abchee et al. (2010) studied this question.

synapsesocial.com/papers/6a1fe107dfff2a7ea2430ca3https://doi.org/10.1097/mca.0b013e328335a042
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