What question did this study set out to answer?

This study aims to derive a formula to determine 99mTc-DTPA clearance from a single plasma sample.

Determination of 99mTc‐DTPA clearance by a single plasma sample method

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Randomized trial demonstrates accurate determination of 99mTc-DTPA clearance in patients, indicating a potential routine method.

This study aims to derive a formula to determine 99mTc-DTPA clearance from a single plasma sample.
Analyzed 99mTc-DTPA time activity curves in 45 patients.
Calculated extracellular volume from body surface area.
Used a formula involving mean transit time from radioactivity in plasma samples.
Calculated clearance (Cl) from the single sample method was r = 0.987 compared to standard multiple sample method.
The method is accurate for individuals with clearance greater than 30 ml min-1.
The method is not applicable for children or patients with lower clearance rates.

Christensen et al. (1986) studied this question.

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