Key result
DAV-vaccinated, B-cell-deficient mice failed to clear viral infection and were no longer protected from Theiler's murine encephalomyelitis virus-mediated central nervous system disease.
B cells and CD4+ T cells are required for vaccine-mediated protection against Theiler's murine encephalomyelitis virus-induced central nervous system disease.
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B-cell requirement for DAV protection in TMEV mice leaves open translation to human CNS viral vaccine design.
The role of humoral immunity in the protection of vaccinated SJL/J mice from central nervous system disease induced by the DA strain (DAV) of Theiler's murine encephalomyelitis virus was investigated in B-cell-deficient mice. Mice were depleted of B cells by treatment with a mouse monoclonal antibody specific for immunoglobulin M. DAV-vaccinated, B-cell-deficient mice failed to clear viral infection and were no longer protected from Theiler's murine encephalomyelitis virus-mediated central nervous system disease. CD4+ T cells are required in this model of protection to provide help for the development of an antiviral antibody response in the central nervous system.
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Kurtz et al. (1995) studied Theiler's murine encephalomyelitis virus-induced central nervous system disease. B-cell depletion via monoclonal antibody specific for IgM vs. B-cell competent mice was evaluated on Clearance of viral infection and protection from central nervous system disease. DAV-vaccinated, B-cell-deficient mice failed to clear viral infection and were no longer protected from Theiler's murine encephalomyelitis virus-mediated central nervous system disease.
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