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Susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by the viral L protein.
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CD4+ T cells play a crucial role in clearing the DA strain of TMEV from the central nervous system in susceptible mice, an activity inhibited by the viral L protein.
DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L* which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L*.
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Xiaoqi Lin (2004) studied Theiler's murine encephalomyelitis virus (TMEV) infection. CD4+ T cells (adoptive transfer) was evaluated on Clearance of DA virus from the central nervous system. Susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by the viral L protein.
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