May 1, 2001AJP Regulatory Integrative and Comparative Physiology

Evidence supporting a physiological role for proANP-(1–30) in the regulation of renal excretion

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Why the study?

Does proANP-(1-30) play a physiological role in regulating renal excretion in rats?

Population

Pentobarbital sodium-anesthetized rats (n=29 total across two studies)

Comparison

Study 1: Synthetic rat proANP- bolus followed by… vs Study 1: 0.45% saline. Study 2: Normal rabbit…

Design

Preclinical

Follow-up

Study 1: six 30-min periods; Study 2: 3 hours

Authors

JDJohn R. DietzDartmouth College DSD. ScottUniversity of South Florida CLCarol S. LandonUniversity of South Florida

Discussion

Member takes

Implication

Supports proANP-(1-30) role in rat renal excretion; hypothesis-generating with translation to humans left open.

Structured PICO

Does proANP-(1-30) play a physiological role in regulating renal excretion in rats?

Population

Pentobarbital sodium-anesthetized rats (n=29 total across two studies)

Intervention

Study 1: Synthetic rat proANP-(1-30) bolus (10 microg) followed by infusion (30 ng/min). Study 2: Pretreatment with rabbit serum containing antibody against proANP-(1-30) prior to volume expansion.

Comparator

Study 1: 0.45% saline. Study 2: Normal rabbit serum.

Outcome

Changes in renal excretion (urine flow, potassium excretion, sodium excretion) and hemodynamics (mean arterial pressure, renal blood flow, glomerular filtration rate)surrogate

The rat sequence of proANP-(1-30) produces natriuresis and diuresis independent of hemodynamics and cGMP, suggesting a physiological role in regulating renal excretion.

Cite This Study

Dietz et al. (2001) studied this question.

synapsesocial.com/papers/6a1ff48c17bd4d7ccf04b287 https://doi.org/10.1152/ajpregu.2001.280.5.r1510

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Evidence supporting a physiological role for proANP-(1–30) in the regulation of renal excretion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence supporting a physiological role for proANP-(1–30) in the regulation of renal excretion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider