August 1, 1994Clinical and Experimental Pharmacology and Physiology

Possible Mechanisms Involved in the Natriuretic Response to Atrial Natriuretic Factor (Anf) and Proanf 31–67 in the Rat

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Population

Anaesthetized rats

Comparison

Intravenous infusion of atrial natriuretic… vs Comparison between ANF and proANF 31-67

Design

Preclinical

Follow-up

40 min

Authors

JDJohn R. DietzDartmouth College DVDavid L. VeselyArkansas Children's Hospital SNS. J. NazianUniversity of South Florida

Discussion

Member takes

Implication

Highlights cGMP-independent natriuresis by proANF 31-67 in rats; leaves open relevance to human heart failure therapies.

Structured PICO

Population

Anaesthetized rats

Intervention

Intravenous infusion of atrial natriuretic factor (ANF) or proANF 31-67 at 10 pmol/min for 40 min

Comparator

Comparison between ANF and proANF 31-67

Outcome

Natriuretic response (sodium excretion)surrogate

Both ANF and proANF 31-67 induce natriuresis via a tubular mechanism, but only ANF's effects appear mediated by cGMP and are associated with decreased arterial pressure.

Cite This Study

Dietz et al. (1994) studied this question.

synapsesocial.com/papers/6a228dfdf56da133636d0661 https://doi.org/10.1111/j.1440-1681.1994.tb02560.x

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Possible Mechanisms Involved in the Natriuretic Response to Atrial Natriuretic Factor (Anf) and Proanf 31–67 in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Possible Mechanisms Involved in the Natriuretic Response to Atrial Natriuretic Factor (Anf) and Proanf 31–67 in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider