Secretion and Renal Effects of Anf Prohormone Peptides

View Full Paper

Ask AI

Bookmark

Population

Rats / rat atria

Design

Preclinical

Authors

Discussion

Hypothesis-generating for cGMP-independent natriuresis in rats; leaves open any human therapeutic role pending prospective studies.

Population

Rats / rat atria

Intervention

Acute stimulation with blood volume expansion, high salt diet, and administration of Pro ANF 31-67

Outcome

Secretion of ANF and pro ANF peptides, plasma concentrations, and natriuresissurrogate

Pro ANF 31-67 induces natriuresis through a mechanism independent of cGMP, PRA, or plasma ANF levels in rats.

Dietz et al. (1995) studied this question.

View Full Paper

Ask AI

Bookmark