Why the study?
Do peptides derived from the NH(2)-terminal portion of the ANF prohormone have natriuretic, kaliuretic, and diuretic properties similar to ANF in anesthetized Munich-Wistar rats?
Population
Anesthetized Munich-Wistar rats
Comparison
Infusion of three peptides from the NH-terminus… vs COOH-terminus peptide [proANF-] and control
Design
Preclinical
Follow-up
120 min
Authors
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These rat findings are hypothesis-generating; human studies needed before clinical consideration.
Do peptides derived from the NH(2)-terminal portion of the ANF prohormone have natriuretic, kaliuretic, and diuretic properties similar to ANF in anesthetized Munich-Wistar rats?
Three peptides from the NH(2)-terminus of the ANF prohormone possess varying degrees of natriuretic, kaliuretic, and diuretic properties similar to ANF.
Martin et al. (1990) studied this question.
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