Key result
A subgroup of diabetic patients showed a progressive decline in creatinine clearance of 4-5 ml/min annually, which occurred even in the absence of significant increases in albuminuria.
Population
211 diabetic patients, with a subgroup analysis of 40 patients who showed progressive increases in albumin…
Design
Cohort
Follow-up
8-14 years
Authors
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May indicate need for GFR monitoring independent of albuminuria in diabetes; leaves open causal implications and intervention targets.
Cohort (n=211)
A subgroup of diabetic patients may experience a progressive decline in renal function independent of significant increases in albuminuria.
Tsalamandris et al. (1994) conducted a cohort in Diabetes (Type I and Type II) (n=211). Albuminuria vs. Absence of albuminuria was evaluated on Progressive increases in albumin excretion rate (AER) and/or decreases in creatinine clearance (CC). A subgroup of diabetic patients showed a progressive decline in creatinine clearance of 4-5 ml/min annually, which occurred even in the absence of significant increases in albuminuria.
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