What is the clinical evidence from this study?

Study design: Other. Population: Hypertension (n=60). Intervention: Olmesartan vs. Atenolol, hydralazine, or vehicle. Primary outcome: ACE2 mRNA in the thoracic aorta (fivefold greater, p=<0.05).

What question did this study set out to answer?

This study aims to explore how angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) in the aorta of spontaneously hypertensive rats.

April 16, 2005AJP Heart and Circulatory Physiology

Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1–7) expression in the aorta of spontaneously hypertensive rats

Q: What are the key findings of this study?

Olmesartan treatment in spontaneously hypertensive rats increased ACE2 mRNA in the thoracic aorta fivefold compared with vehicle (P<0.05), whereas atenolol and hydralazine had no effect.

Q: What question did this study set out to answer?

This study aims to explore how angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) in the aorta of spontaneously hypertensive rats.

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Key result

Olmesartan treatment in spontaneously hypertensive rats increased ACE2 mRNA in the thoracic aorta fivefold compared with vehicle (P<0.05), whereas atenolol and hydralazine had no effect.

Why the study?

Does AT1 receptor blockade with olmesartan increase ACE2 and angiotensin-(1-7) expression and improve vascular remodeling in spontaneously hypertensive rats compared to other antihypertensives or vehicle?

Population

12-wk-old male spontaneously hypertensive rats (SHR), n=60

Comparison

Olmesartan 10 mg/kg/day for 2 weeks vs Atenolol 30 mg/kg/day, hydralazine 10 mg/kg/day…

Design

Preclinical

Follow-up

2 weeks

Authors

MIMichiya IgaseEhime University WSWilliam B. StrawnDuke University PGPatricia E. GallagherWake Forest University

Discussion

Member takes

Implication

Does not inform clinical ARB selection; leaves open whether ACE2 upregulation improves human vascular outcomes beyond BP control.

Key Points

This study aims to explore how angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) in the aorta of spontaneously hypertensive rats.
Male spontaneously hypertensive rats aged 12 weeks were treated with olmesartan, atenolol, hydralazine, or vehicle for 2 weeks.
Systolic blood pressure and ACE2 expression were measured in the thoracic aorta and carotid arteries using mRNA analysis and immunostaining.
Vessel wall dimensions were compared between treatment groups.
Systolic blood pressure was approximately 30% lower in olmesartan-treated rats (P < 0.05).
ACE2 mRNA was fivefold greater in the thoracic aorta of olmesartan-treated rats compared to vehicle-treated rats (P < 0.05).
Olmesartan significantly reduced the thoracic aorta media-to-lumen ratio and media thickness (P < 0.05), whereas no changes were observed in carotid arteries.

Structured PICO

Population

60 12-week-old male spontaneously hypertensive rats treated for 2 weeks to assess the regulation of ACE2 and angiotensin-(1-7) expression.

Intervention

Olmesartan 10 mg/kg/day for 2 weeks

Comparator

Atenolol 30 mg/kg/day, hydralazine 10 mg/kg/day, or vehicle for 2 weeks

Outcome

ACE2 and angiotensin-(1-7) expression in aortas and carotid arteriessurrogate

Main Result

Effect estimate: fivefold greater

p-value: p=<0.05

AT1 receptor blockade with olmesartan increases ACE2 and angiotensin-(1-7) expression and improves vascular remodeling in the thoracic aorta of spontaneously hypertensive rats, independent of blood pressure lowering.

Cite This Study

Igase et al. (2005) studied Hypertension (n=60). Olmesartan vs. Atenolol, hydralazine, or vehicle was evaluated on ACE2 mRNA in the thoracic aorta (fivefold greater, p=<0.05). Olmesartan treatment in spontaneously hypertensive rats increased ACE2 mRNA in the thoracic aorta fivefold compared with vehicle (P<0.05), whereas atenolol and hydralazine had no effect.

synapsesocial.com/papers/6a200c86d4e6d3589704daa8 https://doi.org/10.1152/ajpheart.00068.2005

Topics

Hypertension management

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April 16, 2005AJP Heart and Circulatory Physiology

Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1–7) expression in the aorta of spontaneously hypertensive rats

View Full Paper

Ask AI

Bookmark

Key result

Olmesartan treatment in spontaneously hypertensive rats increased ACE2 mRNA in the thoracic aorta fivefold compared with vehicle (P<0.05), whereas atenolol and hydralazine had no effect.

Why the study?

Population

12-wk-old male spontaneously hypertensive rats (SHR), n=60

Comparison

Olmesartan 10 mg/kg/day for 2 weeks vs Atenolol 30 mg/kg/day, hydralazine 10 mg/kg/day…

Design

Preclinical

Follow-up

2 weeks

Authors

MIMichiya IgaseEhime University WSWilliam B. StrawnDuke University PGPatricia E. GallagherWake Forest University

Discussion

Member takes

Implication

Does not inform clinical ARB selection; leaves open whether ACE2 upregulation improves human vascular outcomes beyond BP control.

Key Points

This study aims to explore how angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) in the aorta of spontaneously hypertensive rats.
Male spontaneously hypertensive rats aged 12 weeks were treated with olmesartan, atenolol, hydralazine, or vehicle for 2 weeks.
Systolic blood pressure and ACE2 expression were measured in the thoracic aorta and carotid arteries using mRNA analysis and immunostaining.
Vessel wall dimensions were compared between treatment groups.
Systolic blood pressure was approximately 30% lower in olmesartan-treated rats (P < 0.05).
ACE2 mRNA was fivefold greater in the thoracic aorta of olmesartan-treated rats compared to vehicle-treated rats (P < 0.05).
Olmesartan significantly reduced the thoracic aorta media-to-lumen ratio and media thickness (P < 0.05), whereas no changes were observed in carotid arteries.

Structured PICO

Population

60 12-week-old male spontaneously hypertensive rats treated for 2 weeks to assess the regulation of ACE2 and angiotensin-(1-7) expression.

Intervention

Olmesartan 10 mg/kg/day for 2 weeks

Comparator

Atenolol 30 mg/kg/day, hydralazine 10 mg/kg/day, or vehicle for 2 weeks

Outcome

ACE2 and angiotensin-(1-7) expression in aortas and carotid arteriessurrogate

Main Result

Effect estimate: fivefold greater

p-value: p=<0.05

Cite This Study

synapsesocial.com/papers/6a200c86d4e6d3589704daa8 https://doi.org/10.1152/ajpheart.00068.2005

Also Consider

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Topics

Hypertension management

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