Key result
Antihypertensive drugs, including RAS inhibitors and calcium channel blockers, may reverse cardiovascular hyperplasia by inducing therapeutic apoptosis independent of blood pressure reduction.
Why the study?
Do antihypertensive drugs induce therapeutic apoptosis to reverse cardiovascular hyperplasia in spontaneously hypertensive rats?
Do antihypertensive drugs induce therapeutic apoptosis to reverse cardiovascular hyperplasia in spontaneously hypertensive rats?
Antihypertensive therapies may reverse cardiovascular hyperplasia by inducing therapeutic apoptosis, an effect that appears independent of blood pressure reduction.
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Should not change clinical practice; hypothesis-generating for apoptosis-mediated effects in hypertensive animal models.
deBlois et al. (2005) conducted a review in Hypertension and cardiovascular hyperplasia. Antihypertensive drugs (RAS inhibitors, calcium channel blockers, beta-blockers) was evaluated on Reversal of cardiovascular hyperplasia via apoptosis. Antihypertensive drugs, including RAS inhibitors and calcium channel blockers, may reverse cardiovascular hyperplasia by inducing therapeutic apoptosis independent of blood pressure reduction.
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