Key result
During aortic occlusion in pigs, intravenous isoproterenol increased stroke volume by 26.3% compared to 3.8% with intracoronary infusion (P<0.01).
Why the study?
Does intravenous versus intracoronary isoproterenol infusion alter the stroke volume response to descending thoracic aorta occlusion in anesthetized pigs?
Does intravenous versus intracoronary isoproterenol infusion alter the stroke volume response to descending thoracic aorta occlusion in anesthetized pigs?
Absolute Event Rate: 26.3% vs 3.8%
p-value: p=<0.01
Intravenous, but not intracoronary, isoproterenol infusion increases stroke volume during aortic occlusion in pigs, likely due to greater increases in end-diastolic segment length and blood redistribution.
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Supports differential stroke volume effects by isoproterenol route in porcine aortic occlusion; leaves open clinical translation.
Vengen et al. (1987) studied this question. Intravenous isoproterenol infusion vs. Intracoronary isoproterenol infusion was evaluated on Change in stroke volume (p=<0.01). During aortic occlusion in pigs, intravenous isoproterenol increased stroke volume by 26.3% compared to 3.8% with intracoronary infusion (P<0.01).
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