Why the study?
Does volume therapy and isoproterenol infusion affect blood flow in aorto-coronary bypass grafts in adult dogs?
Population
Adult dogs subjected to aorto-coronary bypass using the 'internal shunt'-technique
Comparison
Volume expansion, volume withdrawal, and/or… vs Normovolaemic state vs hypovolaemic state
Design
Preclinical
Authors
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Volume status dictates graft flow responses to isoproterenol in bypass models; leaves open translation to human perioperative care.
Does volume therapy and isoproterenol infusion affect blood flow in aorto-coronary bypass grafts in adult dogs?
Blood flow through aorto-coronary bypass grafts is highly dependent on circulating blood volume, which also dictates the hemodynamic response to isoproterenol.
T Kluge (1972) studied this question.
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