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February 18, 2019EP Europace

Spotlight on S-ICD™ therapy: 10 years of clinical experience and innovation

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Key result

Subcutaneous ICD therapy demonstrates promising performance and efficacy in patients beyond classical indications, including those with Brugada syndrome or hypertrophic cardiomyopathy.

Why the study?

S-ICD therapy indications are broadening beyond classical candidates without coverage by randomized controlled trials, creating a need for an updated review of empirical evidence and technical advancements in expanded indications.

Design

Review

Authors

NBNils BögeholzKWKevin WillyPNPhilipp Niehues

Discussion

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Overview

May support S-ICD consideration in Brugada syndrome and HCM; leaves open need for prospective trials.

Structured PICO

P
Population
Patients considered for or receiving Subcutaneous ICD (S-ICD) therapy, including those with Brugada syndrome, hypertrophic cardiomyopathy, or distinct obesity
I
Intervention
Subcutaneous ICD (S-ICD) therapy

This review highlights the expanding indications and promising performance of S-ICD therapy beyond classical candidates, including in complex conditions like Brugada syndrome and hypertrophic cardiomyopathy.

Limitations

  • The decision for S-ICD implantation is still not covered by controlled randomized trials but rather relies on patient series or observational studies.

Cite This Study

Bögeholz et al. (2019) conducted a review in Patients requiring ICD therapy without demand for pacing. Subcutaneous ICD (S-ICD) therapy was evaluated. Subcutaneous ICD therapy demonstrates promising performance and efficacy in patients beyond classical indications, including those with Brugada syndrome or hypertrophic cardiomyopathy.

synapsesocial.com/papers/6a2011ac9d62e9997c04bf13https://doi.org/10.1093/europace/euz029
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety and Efficacy of the Totally Subcutaneous Implantable Defibrillator2015 · 500 citations
  2. 2Long-Term Clinical Outcomes of Subcutaneous Versus Transvenous Implantable Defibrillator Therapy2016 · 179 citations
  3. 3The Design of the Understanding Outcomes with the S‐ICD in Primary Prevention Patients with Low EF Study (UNTOUCHED)2016 · 24 citations
  4. 4Which Patients Are Not Suitable for a Subcutaneous ICD: Incidence and Predictors of Failed QRS‐T‐Wave Morphology Screening2013 · 132 citations
  5. 5Intraoperative Defibrillation Testing Should Not Be Generally Abandoned for All ICD Procedures—A Multicenter Study on 4,572 Consecutive Patients2016 · 6 citations