Key result
Sequential A-V biventricular pacing reduces left ventricular outflow tract gradient and improves functional capacity in selected patients with hypertrophic obstructive cardiomyopathy when fusion with intrinsic rhythm is avoided.
May expand pacing options in selected HOCM; leaves open need for randomized confirmation.
[first paragraph of article]About one-third of patients with hypertrophic cardiomyopathy (HCM) have resting left ventricular outflow tract obstruction (LVOTO). The presence of LVOTO in HCM facilitates the progression of heart failure and increases the risk of death. LVOTO is defined as a peak instantaneous Doppler LV outflow tract gradient ≥30 mmHg, but the threshold for invasive treatment is usually considered to be ≥50 mm Hg.
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Tolosana et al. (2018) conducted a review in Hypertrophic obstructive cardiomyopathy. Cardiac pacing (Sequential DDD-AV and Biventricular pacing) was evaluated. Sequential A-V biventricular pacing reduces left ventricular outflow tract gradient and improves functional capacity in selected patients with hypertrophic obstructive cardiomyopathy when fusion with intrinsic rhythm is avoided.
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