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January 1, 2009Journal of EpidemiologyOpen Access

Heritability of Serum Apolipoprotein Concentrations in Middle-Aged Japanese Twins

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Key result

Genetic factors accounted for 16% to 75% of the total variance in serum apolipoprotein concentrations among middle-aged Japanese twins, with heritability being consistently higher in females than in males.

Population

142 Japanese twin pairs, aged 45 through 65 years, including 85 monozygotic pairs and 57 same-sexed…

Design

Cross-sectional

Authors

YCYang CaiKHKazuo HayakawaTosei General HospitalRNReiko NishiharaBrigham and Women's Hospital

Discussion

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Overview

No immediate clinical implications; hypothesis-generating for sex-specific genetic influences on apolipoprotein levels.

Study Design

Type

Observational (n=284)

Multicenter

No

Structured PICO

P
Population
284 middle-aged Japanese twins (142 pairs) aged 45 to 65 years, evaluated for genetic and environmental influences on serum apolipoprotein concentrations.
O
Outcome
Heritability (genetic and environmental causes of individual differences) of serum concentrations of apolipoproteins (Apo A-I, apo A-II, apo B, apo C-II, apo C-III, and apo E)surrogate

Main Result

Effect estimate: 16% to 75% heritability

Genetic factors significantly influence serum apolipoprotein levels in middle-aged Japanese twins, with heritability being higher in females than in males.

Limitations

  • The number of subjects was not large, resulting in large 95% confidence intervals and relatively low statistical power.

Cite This Study

Cai et al. (2009) conducted an observational in Healthy (assessing apolipoprotein concentrations) (n=284). Genetic factors (Zygosity) vs. Environmental factors was evaluated on Heritability of serum apolipoprotein concentrations (16% to 75% heritability). Genetic factors accounted for 16% to 75% of the total variance in serum apolipoprotein concentrations among middle-aged Japanese twins, with heritability being consistently higher in females than in males.

synapsesocial.com/papers/6a2011d8d5e8712fdf65c6e2https://doi.org/10.2188/jea.je20081037
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Also Consider

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  1. 1Twin Studies of Coronary Heart Disease and Its Risk Factors1984 · 93 citations
  2. 2STUDIES ON SIMILARITY DIAGNOSIS IN TWINS WITH THE AID OF MAILED QUESTIONNAIRES1961 · 309 citations
  3. 3GENETIC HERITABILITY AND COMMON ENVIRONMENTAL COMPONENTS OF RESTING AND STRESSED BLOOD PRESSURES, LIPIDS, AND BODY MASS INDEX IN UTAH PEDIGREES AND TWINS1989 · 289 citations
  4. 4Utility of the Apolipoprotein E Genotype in the Diagnosis of Alzheimer's Disease1998 · 550 citations
  5. 5Twin study of genetic and environmental effects on lipid levels1988 · 52 citations