Key result
Males with cardiac sequelae due to Kawasaki disease had a significantly elevated mortality rate after the acute phase compared to the general population (SMR 2.77).
Why the study?
Does a history of Kawasaki disease increase mortality compared to an age-matched healthy population?
Population
6,576 patients with a new definite diagnosis of Kawasaki disease enrolled between July 1982 and December 1992
Design
Cohort
Follow-up
Followed until December 31, 1997, or death (up to 15 years)
Authors
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Supports targeted surveillance in males with cardiac sequelae; leaves open generalizability and causal mechanisms.
Cohort (n=6,576)
Yes
Does a history of Kawasaki disease increase mortality compared to an age-matched healthy population?
Effect estimate: SMR 2.77
Absolute Event Rate: 6% vs 2.2%
Males with cardiac sequelae from Kawasaki disease have a significantly higher long-term mortality rate than the general population, highlighting the need for continued surveillance in this high-risk subgroup.
Nakamura et al. (2000) conducted a cohort in Kawasaki disease (n=6,576). History of Kawasaki disease with cardiac sequelae vs. Age- and sex-matched general population was evaluated on Mortality after the acute phase (SMR 2.77). Males with cardiac sequelae due to Kawasaki disease had a significantly elevated mortality rate after the acute phase compared to the general population (SMR 2.77).
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