Key result
A history of Kawasaki disease was not associated with increased overall mortality compared to the general population (SMR 1.00), although mortality was significantly elevated among the subgroup with cardiac sequelae (SMR 1.86).
Why the study?
Does a history of Kawasaki disease increase long-term mortality in Japanese patients?
Population
6,576 Japanese patients with a new definite diagnosis of Kawasaki disease between July 1982 and December 1992
Design
Cohort
Follow-up
Followed until December 31, 2009 (up to 27 years)
Authors
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Long-term mortality after KD matches population norms; leaves open questions on nonfatal cardiovascular sequelae and surveillance needs.
Cohort (n=6,576)
Yes
Does a history of Kawasaki disease increase long-term mortality in Japanese patients?
Effect estimate: SMR 1.00 (95% CI 0.73-1.34)
Long-term mortality in Kawasaki disease patients is driven by those with cardiac sequelae, who have nearly double the mortality risk of the general population.
Nakamura et al. (2013) conducted a cohort in Kawasaki disease (n=6,576). History of Kawasaki disease vs. General Japanese population was evaluated on All-cause mortality (Standardized Mortality Ratio) (SMR 1.00, 95% CI 0.73-1.34). A history of Kawasaki disease was not associated with increased overall mortality compared to the general population (SMR 1.00), although mortality was significantly elevated among the subgroup with cardiac sequelae (SMR 1.86).
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