What question did this study set out to answer?

This research aims to understand how HDL-cholesterol mediates the effects of alcohol on coronary heart disease in middle-aged men.

Alcohol and coronary heart disease: the roles of HDL‐cholesterol and smoking

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial examines HDL-cholesterol's role in alcohol-related coronary heart disease risk in men, indicating smoker-specific effects.

This research aims to understand how HDL-cholesterol mediates the effects of alcohol on coronary heart disease in middle-aged men.
Cox proportional hazard models were employed to analyze CHD risks across different HDL-cholesterol and smoking categories.
The trial was a multicentre, placebo-controlled, double-blind study involving dyslipidaemic middle-aged men with alcohol data.
Data from the placebo arm of the Helsinki Heart Study over a 5-year duration was analyzed.
A U-shaped association between alcohol consumption and CHD risk was observed, with protective effects in low and normal HDLc groups showing 23% and 36% risk reductions, respectively.
In non-smokers, alcohol provided virtually no protection against CHD. In high alcohol consumers (800 g/year), the incidence was 6/1000 for those with frequent drinking compared to 11/1000 for weekend drinkers.
The study suggests that the role of HDL-cholesterol in mediating alcohol's protective effects is less significant than previously thought.

Mänttäri et al. (1997) studied this question.

View Full Paper

Ask AI

Bookmark

Randomized trial examines HDL-cholesterol's role in alcohol-related coronary heart disease risk in men, indicating smoker-specific effects.