Key result
Under abnormal RyR conditions, triggered activity and spontaneous calcium release occurred preferentially near the epicardium compared to the endocardium (P<0.01).
p-value: p=<0.01
Abnormal ryanodine receptor function leads to triggered activity driven by spontaneous calcium release events, preferentially near the epicardium due to faster calcium reuptake kinetics, providing a mechanism for multifocal arrhythmias.
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Does not inform clinical practice; leaves open epicardial targeting as a mechanism in RyR-related arrhythmias.
Katra et al. (2006) studied Arrhythmogenesis (n=28). Abnormal RyR conditions induced by FKBP12.6 dissociation and beta-adrenergic stimulation vs. Control, rapamycin alone, or isoproterenol alone was evaluated on Triggered activity and spontaneous calcium release (SCR) events (p=<0.01). Under abnormal RyR conditions, triggered activity and spontaneous calcium release occurred preferentially near the epicardium compared to the endocardium (P<0.01).
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