Key result
Enhanced calcium entry significantly increased cytoplasmic calcium elevation at the endocardium during rapid pacing compared with control (15% vs 10%, P<0.04) in a canine wedge model.
Absolute Event Rate: 15% vs 10%
p-value: p=<0.04
In a canine wedge model, spontaneous calcium release events near the endocardium under calcium overload conditions initiate DAD-mediated triggered activity, providing a potential mechanism for polymorphic VT.
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May link endocardial calcium overload to DAD-triggered activity; hypothesis-generating for polymorphic VT mechanisms.
Katra et al. (2005) studied Calcium overload and triggered activity. Enhanced calcium entry (I(Ks) blockade with beta-adrenergic stimulation) vs. Control conditions was evaluated on Cytoplasmic calcium elevation at the endocardium during rapid pacing (p=<0.04). Enhanced calcium entry significantly increased cytoplasmic calcium elevation at the endocardium during rapid pacing compared with control (15% vs 10%, P<0.04) in a canine wedge model.
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