Key result
In a canine model, heart failure tissue exhibited reduced calcium transient amplitude (135 vs 170 RU) and increased triggered activity, which was associated with the rate of spontaneous calcium release rise rather than its amplitude.
Absolute Event Rate: 135% vs 170%
p-value: p=<0.05
In failing canine myocardium, the rate of spontaneous calcium release rise, rather than its amplitude, is the critical determinant of triggered arrhythmias.
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Aggregate SCR may trigger arrhythmias in HF; leaves open whether targeting peak amplitude improves outcomes.
Hoeker et al. (2009) studied Heart failure (n=24). Tachycardia-induced heart failure vs. Normal canines was evaluated on Steady-state calcium transient amplitude (ratiometric units) (p=<0.05). In a canine model, heart failure tissue exhibited reduced calcium transient amplitude (135 vs 170 RU) and increased triggered activity, which was associated with the rate of spontaneous calcium release rise rather than its amplitude.
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