Key result
Recoil force generated during fluid propulsion was maximal for an annulus diameter close to the normal adult value, and smaller for diameters corresponding to stenotic valves or dilated cardiomyopathy.
Population
Simplified mechanical model emulating the atrioventricular system during the rapid filling phase of diastole
Comparison
Variation of mitral annulus diameter vs Normal adult mitral annulus diameter
Design
Preclinical
Authors
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Recoil optimization at normal annulus size may inform valve design; leaves open human translation from animal models.
In an experimental mechanical model, the recoil force during ventricular rapid filling is optimized at a normal mitral annulus diameter, with reductions seen in simulated stenotic or dilated states.
Kheradvar et al. (2007) studied Mitral valve dynamics and vortex ring formation. Mitral annulus diameter variation vs. Normal adult annulus diameter was evaluated on Recoil force on the displaced annulus plane. Recoil force generated during fluid propulsion was maximal for an annulus diameter close to the normal adult value, and smaller for diameters corresponding to stenotic valves or dilated cardiomyopathy.
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