Key result
Peritoneal dialysis is linked to a ~10% reduction in Global Work Index in ESRD.
Why the study?
Dialysis initiation introduces new cardiovascular challenges in end-stage renal disease, but the short-term changes in left ventricular myocardial function during early peritoneal dialysis were unclear.
Does short-term peritoneal dialysis improve left ventricular myocardial work and strain in patients with end-stage renal disease?
Cohort (n=83)
No
Does short-term peritoneal dialysis improve left ventricular myocardial work and strain in patients with end-stage renal disease?
Absolute Event Rate: 1685.93% vs 1882.41%
p-value: p=<0.05
Short-term peritoneal dialysis improves load-independent markers of left ventricular myocardial work, especially when initiated prior to the development of significant hyperphosphatemia.
Short-term PD was associated with improved myocardial work in ESRD; hypothesis-generating and requires randomized confirmation before practice change.
BACKGROUND: Initiation of dialysis encompasses new cardiovascular challenges on patients with end-stage renal disease (ESRD). This study used two-dimensional speckle-tracking echocardiography (2D-STE) to investigate the change of left ventricular (LV) myocardial function undergoing peritoneal dialysis (PD) within 1-3 months. METHODS: A total of 56 patients with ESRD and 27 healthy controls were enrolled in this prospective study. Mean duration of PD was 44.41 ± 16.44 days. We evaluated LV myocardial function of patients with ESRD in baseline and within 1-3 months after PD by 2D-STE with global longitudinal strains (GLS) and myocardial work (MW). Based on the level of serum phosphate before PD, patients were divided into two groups: the group with normal serum phosphate or hyperphosphatemia. RESULTS: = .013). CONCLUSIONS: Short-term PD treatment improved LV MW in ESRD patients. They benefited more when receiving treatment before the increase of serum phosphorus.
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Wan et al. (2023) conducted a cohort in End-stage renal disease (n=83). Peritoneal dialysis vs. Pre-dialysis baseline and healthy controls was evaluated on Change in Global Work Index (GWI) (p=<0.05). Short-term peritoneal dialysis significantly reduced myocardial work parameters such as Global Work Index compared to pre-dialysis baseline, reflecting improved cardiac function in patients with end-stage renal disease.
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