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November 28, 2021CARDIOVASCULAR THERAPY AND PREVENTIONOpen Access

Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status

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Why the study?

To study structural and functional myocardial characteristics in patients with exertional angina and type 2 diabetes versus those without diabetes to identify combined hemodynamic changes.

Does the presence of type 2 diabetes worsen structural and functional myocardial characteristics in patients with chronic coronary artery disease?

Comparison

CAD with type 2 diabetes vs CAD without diabetes

Design

Observational comparative study

Authors

MKM. A. KokozhevaResearch Institute of Emergency CareБМБ. У. МардановCentral State HospitalEPE. A. PoddubskayaSechenov University

Discussion

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Implication

May warrant closer monitoring in CAD with diabetes; leaves open causal mechanisms and intervention effects.

Structured PICO

Does the presence of type 2 diabetes worsen structural and functional myocardial characteristics in patients with chronic coronary artery disease?

P
Population
100 patients with chronic coronary artery disease (CAD) and exertional angina, including 49 with type 2 diabetes (mean age 57.9±1.04 years, 35 male/14 female) and 51 without diabetes (mean age 60.2±0.9 years, 34 male/17 female).
I
Intervention
Presence of type 2 diabetes (observational exposure)
C
Comparator
Absence of type 2 diabetes
O
Outcome
Structural and functional myocardial characteristics assessed by resting electrocardiography, transthoracic echocardiography, and cycle ergometrysurrogate

The combination of chronic CAD and type 2 diabetes is associated with worse central and intracardiac hemodynamics, left ventricular hypertrophy, and reduced exercise tolerance compared to CAD alone.

Cite This Study

Kokozheva et al. (2021) studied this question.

synapsesocial.com/papers/6a202dff68c22b15ac2947d7https://doi.org/10.15829/1728-8800-2021-3077
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiographic Changes in Newly Diagnosed Type 2 Diabetes Mellitus Patients with and without Hypertension2020 · 21 citations
  2. 2Study of exercise treadmill test in type 2 diabetes mellitus patients2021 · 3 citations
  3. 32013 ESH/ESC Guidelines for the management of arterial hypertension2013 · 13,686 citations
  4. 4Screening for Glucose Perturbations and Risk Factor Management in Dysglycemic Patients With Coronary Artery Disease—A Persistent Challenge in Need of Substantial Improvement: A Report From ESC EORP EUROASPIRE V2020 · 79 citations
  5. 5NCD Countdown 2030: worldwide trends in non-communicable disease mortality and progress towards Sustainable Development Goal target 3.42018 · 1,387 citations