Key result
An FFR <0.75 significantly correlated with the redistribution of 201Tl (p<0.0001), demonstrating a sensitivity of 79% and specificity of 73% for detecting myocardial ischemia.
Why the study?
Does coronary pressure-derived fractional flow reserve correlate with Thallium-201 myocardial perfusion defects in patients with suspected or known coronary artery disease?
Cross-Sectional (n=165)
No
Does coronary pressure-derived fractional flow reserve correlate with Thallium-201 myocardial perfusion defects in patients with suspected or known coronary artery disease?
Effect estimate: r=-0.62
p-value: p=<0.0001
FFR <0.75 correlates significantly with scintigraphic evidence of myocardial ischemia on Thallium-201 imaging, supporting its use as a reliable marker of ischemia in real-world clinical settings.
Authors
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FFR <0.75 links to Thallium-201 defects in cross-sectional data; leaves open prospective outcome validation before guiding practice.
Yanagisawa et al. (2002) conducted a cross-sectional in Coronary artery disease (n=165). Fractional Flow Reserve (FFR) <0.75 vs. Thallium-201 myocardial perfusion imaging was evaluated on Detection of myocardial ischemia (redistribution of 201Tl) (r=-0.62, p=<0.0001). An FFR <0.75 significantly correlated with the redistribution of 201Tl (p<0.0001), demonstrating a sensitivity of 79% and specificity of 73% for detecting myocardial ischemia.
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