Disease Expression and Outcomes in Black and White Adults With Hypertrophic Cardiomyopathy
Key result
Black adults with hypertrophic cardiomyopathy had significantly higher rates of sub-basal hypertrophy (38.6% vs 14.9%, P<0.001) and appropriate ICD interventions than White adults.
Why the study?
There is limited research on HCM in diverse populations, with a lack of comprehensive data on disease expression, comorbidities, and outcomes in Black individuals.
Do structural HCM characteristics, comorbidities, and outcomes differ between Black and White adults with hypertrophic cardiomyopathy?
Population
434 adults with HCM who self-identified as Black/African American or White
Comparison
Black patients vs White patients
Design
Subgroup analysis from a longitudinal prospective study with supplemental chart review
Authors
Discussion
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Member takes
Implication
May support race-conscious arrhythmia surveillance in HCM; leaves open prospective validation of phenotype-driven risk stratification.
Study Design
Type
Cohort (n=434)
Structured PICO
Do structural HCM characteristics, comorbidities, and outcomes differ between Black and White adults with hypertrophic cardiomyopathy?
P
Population
434 adults (≥18 years) with a clinical diagnosis of hypertrophic cardiomyopathy, self-identifying as Black or White, evaluated in a longitudinal prospective study.
E
Exposure
Black race (observational exposure)
C
Comparator
White race
O
Outcome
Structural HCM characteristics, comorbidities, and outcomescomposite
Main Result
Absolute Event Rate: 38.6% vs 14.9%
p-value: p=<0.001
Black adults with hypertrophic cardiomyopathy present at a younger age with more severe structural abnormalities, higher rates of cardiac fibrosis, and more frequent appropriate ICD interventions compared to White adults.
Cite This Study
Arabadjian et al. (2021) conducted a cohort in Hypertrophic cardiomyopathy (n=434). Black race vs. White race was evaluated on Sub-basal hypertrophy (p=<0.001). Black adults with hypertrophic cardiomyopathy had significantly higher rates of sub-basal hypertrophy (38.6% vs 14.9%, P<0.001) and appropriate ICD interventions than White adults.