Comparison of arterial intimal clearances of LDL from diabetic and nondiabetic cholesterol-fed rabbits. Differences in intimal clearance explained by size differences.
Why the study?
Does the source of LDL (diabetic vs nondiabetic cholesterol-fed rabbits) affect its arterial intimal clearance?
Population
Diabetic and nondiabetic cholesterol-fed rabbits, and normal rabbits
Comparison
Injection of 125I-labeled low density… vs Injection of 131I-labeled low density…
Design
Preclinical
Authors
Discussion
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Implication
LDL particle size, not diabetic origin, may govern arterial clearance in rabbits; leaves open relevance to human atherosclerosis.
Structured PICO
Does the source of LDL (diabetic vs nondiabetic cholesterol-fed rabbits) affect its arterial intimal clearance?
P
Population
Diabetic and nondiabetic cholesterol-fed rabbits, and normal rabbits
I
Intervention
Injection of 125I-labeled low density lipoproteins from diabetic cholesterol-fed rabbits (D-LDL)
C
Comparator
Injection of 131I-labeled low density lipoproteins from nondiabetic cholesterol-fed rabbits (N-LDL)
O
Outcome
Arterial intimal clearance of LDLsurrogate
Differences in arterial intimal clearance of LDL between diabetic and nondiabetic rabbits are explained by differences in LDL particle size rather than the diabetic state itself.
Cite This Study
Nordestgaard et al. (1989) studied this question.