Why the study?
Does the inhibition of NO synthase, calcium-activated potassium channels, and cytochrome epoxygenases reduce sustained conduit artery flow-mediated dilatation in healthy subjects?
Population
12 healthy subjects
Comparison
Local infusion of inhibitors of NO synthase… vs Local infusion of saline
Design
Other
Key result
Maximal radial artery flow-mediated dilatation was decreased by l-NMMA (-39%), tetraethylammonium chloride (-14%), fluconazole (-18%), and their combinations (up to -71%) compared to saline.
Authors
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Implicates NO-EDHF synergy in healthy conduit FMD; leaves open translation to patients or therapeutic targeting.
Does the inhibition of NO synthase, calcium-activated potassium channels, and cytochrome epoxygenases reduce sustained conduit artery flow-mediated dilatation in healthy subjects?
This study demonstrates that both NO and a cytochrome-related EDHF are involved in peripheral conduit artery flow-mediated dilatation in humans during sustained flow conditions, with synergistic effects suggesting functional interaction.
Bellien et al. (2006) studied Healthy (n=12). Inhibitors of NO synthase, calcium-activated potassium channels, and cytochrome epoxygenases vs. Saline was evaluated on Maximal radial artery flow-mediated dilatation. Maximal radial artery flow-mediated dilatation was decreased by l-NMMA (-39%), tetraethylammonium chloride (-14%), fluconazole (-18%), and their combinations (up to -71%) compared to saline.