Key result
Obesity profoundly but reversibly suppresses growth hormone secretion in children and adults, complicating the differentiation between obesity and growth hormone deficiency.
Population
Children and adults with obesity
Design
Review
Authors
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Obesity warrants cautious GH testing interpretation to avoid misdiagnosing deficiency; leaves open optimal obesity-adjusted diagnostic thresholds.
This review summarizes the mechanisms underlying the reversible suppression of growth hormone secretion in obesity and discusses the validity of provocative testing for GH deficiency in overweight subjects.
Kreitschmann‐Andermahr et al. (2010) conducted a review in Obesity. Obesity was evaluated. Obesity profoundly but reversibly suppresses growth hormone secretion in children and adults, complicating the differentiation between obesity and growth hormone deficiency.
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