Key result
Shear wave elastography demonstrated high diagnostic accuracy for evaluating renal fibrosis in patients with chronic kidney disease, with a pooled sensitivity of 84%, specificity of 80%, and a diagnostic odds ratio of 21.50.
Why the study?
Chronic kidney disease leads to high morbidity and mortality, making it important to quantify disease severity by evaluating renal parenchymal stiffness using shear wave elastography.
Does shear wave elastography accurately evaluate renal parenchymal stiffness and fibrosis in patients with chronic kidney disease?
Meta-Analysis (n=405)
Does shear wave elastography accurately evaluate renal parenchymal stiffness and fibrosis in patients with chronic kidney disease?
Odds Ratio: 21.5 (95% CI 14.69–31.46)
Shear wave elastography is a highly accurate, noninvasive imaging technique for evaluating renal parenchymal stiffness and fibrosis in patients with chronic kidney disease.
Supports noninvasive renal fibrosis assessment in CKD; confirms high diagnostic accuracy across studies.
Background: Chronic kidney disease (CKD) is a progressive loss of renal function, mainly due to hypertension, diabetes, and primary kidney disease. The histopathological findings are that of glomerulosclerosis, tubulointerstitial fibrosis and loss of renal parenchyma characterized. Therefrom, CKD can lead to higher morbidity and mortality. Patients with CKD have multiple risk factors, and the prevention work is complicated and arduous. Therefore, it is important to quantify the severity of CKD. The aim of this study is to investigate the value of shear wave elastography (SWE) in the evaluating renal parenchymal stiffness in patients with CKD. Methods: We carried out the systematic search of databases for publications in PubMed, Embase and Cochrane Library on SWE evaluating renal fibrosis in patients with CKD. The Endnote X9, STATA 16, Review Manager 5.3 and other software were used to sort out documents, extract, integrate and analyze data. Results: The outcomes were utilized to appraise the diagnostic accuracy of SWE and diagnose the CKD with renal fibrosis. A total of 405 patients were enrolled and their data analysis results were as follows: summary of sensitivity (S-SEN) 84% (95% confidence interval (CI): 80-87%); specificity (S-SPE) 80% (95% CI: 76-84%); summary of DLR (digital light radiography) positive (DLR-P) 4.29 (95% CI: 3.43 - 5.37); and DLR negative (DLR-N) 0.20 (95% CI: 0.16 - 0.25). The corresponding areas under the curves of diagnostic odds ratio (DOR) and summary receiver operating characteristic curve (SROC) were 21.50 (95% CI: 14.69 - 31.46) and 89% (95% CI: 86-92%), respectively. Conclusions: SWE is highly accurate and has clinical significance for evaluating renal fibrosis, especially when the shear modulus value is used as the threshold.
No takes yet. Share an insight, caveat, or question.
Mo et al. (2022) conducted a meta-analysis in Chronic kidney disease (n=405). Shear wave elastography vs. Clinical diagnosis or laboratory tests was evaluated on Diagnostic accuracy for renal fibrosis (DOR 21.50, 95% CI 14.69-31.46). Shear wave elastography demonstrated high diagnostic accuracy for evaluating renal fibrosis in patients with chronic kidney disease, with a pooled sensitivity of 84%, specificity of 80%, and a diagnostic odds ratio of 21.50.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: