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August 2, 2023American Heart Journal Plus Cardiology Research and PracticeOpen Access

A randomized controlled trial evaluating a theory driven, complex intervention centered on task sharing and mobile health to improve selfcare and outcomes in heart failure – The PANACEA-HF RCT: Design and rationale

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Why the study?

A three-pronged complex intervention underpinned by the extant cycle theory was developed to improve selfcare and deliver whole person care for patients with heart failure.

Population

301 patients aged ≥ 18 years with heart failure

Comparison

Three-pronged complex intervention vs not reported

Design

3-centre, 2-arm, 1:1, open, adaptive stratified, randomized controlled trial

Key result

A trial evaluating a complex intervention for heart failure recruited 301 patients (mean age 59.8 years), with 94.1% in the intervention arm having a Selfcare in Heart Failure Index score ≤70.

Authors

DKDeepak KamathJAJ. AbdullakuttyBGBradi B. Granger

Discussion

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Overview

High self-care deficits predominate in heart failure trial populations; extends rationale for complex interventions targeting knowledge barriers.

Study Design

Type

RCT (n=301)

Blinding

Open-label

Randomization

1:1, adaptive stratified

Multicenter

Yes

PICO

P
Population
301 patients aged ≥18 years with heart failure on guideline-directed medical therapy and a high ceiling diuretic.
I
Intervention / Comparator
Complex intervention (lay health worker assessment, m-health remote monitoring, and dose optimization)

Cite This Study

Kamath et al. (2023) conducted an RCT in heart failure (n=301). Complex intervention (lay health worker assessment, m-health remote monitoring, and dose optimization) was evaluated. A trial evaluating a complex intervention for heart failure recruited 301 patients (mean age 59.8 years), with 94.1% in the intervention arm having a Selfcare in Heart Failure Index score ≤70.

synapsesocial.com/papers/6a207e5e5654e44f693e86a5https://doi.org/10.1016/j.ahjo.2023.100310
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