Sex, ageing and resting blood pressure: gaining insights from the integrated balance of neural and haemodynamic factors
Key result
Sympathetic nerve activity increases with age, and the protective β-adrenergic vasodilatation seen in young women is lost after menopause, contributing to increased blood pressure in older women.
Population
Men and women across different ages (young vs older/postmenopausal)
Design
Review
Authors
Discussion
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Implication
May inform sex-specific hypertension mechanisms in older women; leaves open prospective trials on β-adrenergic modulation.
Structured PICO
P
Population
Men and women across different ages (young vs older/postmenopausal)
This review highlights that the loss of protective beta-adrenergic vasodilatation after menopause contributes to the increased risk of hypertension in older women.
Cite This Study
Hart et al. (2012) conducted a review in Hypertension and blood pressure regulation. Ageing and sex differences (sympathetic nerve activity) was evaluated. Sympathetic nerve activity increases with age, and the protective β-adrenergic vasodilatation seen in young women is lost after menopause, contributing to increased blood pressure in older women.