What question did this study set out to answer?

This research aims to determine the influence of vasopressin on baroreceptor reflexes in humans.

May 1, 1992AJP Heart and Circulatory Physiology

Baroreflex modulation of sympathetic outflow during physiological increases of vasopressin in humans

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Why the study?

Does vasopressin influence the baroreceptor reflex in healthy humans?

Population

18 healthy subjects (8 in protocol 1, 10 in protocol 2)

Comparison

Vasopressin infusion vs Phenylephrine infusion or baseline

Design

Other

Authors

TEThomas J. EbertCross-Cutting Cardiology ACAllen W. CowleyPreventive Cardiology

Discussion

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Implication

Physiological vasopressin may potentiate sympathetic activation during hypotension; hypothesis-generating for effects in cardiovascular disease.

Key Points

This research aims to determine the influence of vasopressin on baroreceptor reflexes in humans.
Eight healthy subjects received sequential infusions of nitroprusside and phenylephrine to alter baroreceptor input.
Muscle sympathetic nerve activity was recorded to assess baroreceptor reflex modulation.
A second protocol involved ten subjects comparing reflex inhibition effects of phenylephrine and vasopressin.
Cardiac and sympathetic baroreflex gains did not differ between pressor agents.
Post-vasopressin sympathoexcitation was significantly enhanced when baroreceptors were unloaded compared to post-phenylephrine infusion.
Increased levels of vasopressin did not alter baroreflex responses at lower doses, but higher doses may enhance sympathetic responses.

Structured PICO

Does vasopressin influence the baroreceptor reflex in healthy humans?

Population

18 healthy subjects (8 in protocol 1, 10 in protocol 2)

Intervention

Vasopressin infusion (subpressor and pressor doses)

Comparator

Phenylephrine infusion or baseline

Outcome

Baroreceptor reflex modulation of efferent vasoconstrictor drive (muscle sympathetic nerve activity and heart rate)surrogate

Physiological increases in vasopressin to higher levels enhance the sympathetic response to baroreceptor unloading in humans.

Cite This Study

Ebert et al. (1992) studied this question.

synapsesocial.com/papers/6a207ff0b9ae31350fa5e159 https://doi.org/10.1152/ajpheart.1992.262.5.h1372

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Implication

Physiological vasopressin may potentiate sympathetic activation during hypotension; hypothesis-generating for effects in cardiovascular disease.

Baroreflex modulation of sympathetic outflow during physiological increases of vasopressin in humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Baroreflex modulation of sympathetic outflow during physiological increases of vasopressin in humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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