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February 1, 1991The Journal of Infectious Diseases

Genome Analysis of Adenovirus Type 31 Strains from Immunocompromised and Immunocompetent Patients

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Population

79 Adenovirus type 31 (Ad31) isolates from immunocompromised (n=15) and immunocompetent patients

Comparison

Restriction endonuclease analysis vs Comparison between isolates from immunocompetent…

Design

Other

Authors

MJMats E. JohanssonCenters for Disease Control and PreventionMBMartha BrownUniversity of TorontoJHJohn C. HierholzerNational Center for Disease Control and Public Health

Discussion

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Overview

Ad31 genomic diversity does not pinpoint virulent strains in immunocompromised patients; leaves open other determinants of clinical severity.

Structured PICO

P
Population
79 Adenovirus type 31 (Ad31) isolates from immunocompromised (n=15) and immunocompetent patients
I
Intervention
Restriction endonuclease analysis
C
Comparator
Comparison between isolates from immunocompetent and immunodeficient hosts
O
Outcome
Identification of genome types and genomic clusters

Genome analysis of Ad31 isolates revealed multiple genome types and clusters, but no specific highly virulent strain was associated with immunocompromised patients despite high clinical severity.

Cite This Study

Johansson et al. (1991) studied this question.

synapsesocial.com/papers/6a2081c991442e0eebcd417chttps://doi.org/10.1093/infdis/163.2.293
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