October 1, 1989Circulation ResearchOpen Access

Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.

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Why the study?

Does minoxidil sulfate alter electrophysiological properties and inhibit contractions in rabbit portal vein smooth muscle cells?

Population

Isolated smooth muscle cells and strips from rabbit portal vein

Comparison

Minoxidil sulfate at micromolar concentrations vs Control conditions

Design

Preclinical

Authors

NLNormand LeblancUniversity of Nevada, Reno DWDixon W. WildeEKOS Corporation KKKathleen D. KeefUniversity of Nevada, Reno

Discussion

Member takes

Implication

Hypothesis-generating for minoxidil's vascular ion channel effects; leaves open human translation.

Structured PICO

Does minoxidil sulfate alter electrophysiological properties and inhibit contractions in rabbit portal vein smooth muscle cells?

Population

Isolated smooth muscle cells and strips from rabbit portal vein

Intervention

Minoxidil sulfate (MNXS) at micromolar concentrations (e.g., 2-5 microM)

Comparator

Control conditions (norepinephrine alone or absence of MNXS)

Outcome

Electrophysiological and mechanical properties (membrane potential, K+ conductance, Ca2+ currents, and norepinephrine-induced contractions)surrogate

Minoxidil sulfate induces vasodilation by promoting K+ conductance and inhibiting L-type Ca2+ channels in vascular smooth muscle cells.

Cite This Study

Leblanc et al. (1989) studied this question.

synapsesocial.com/papers/6a2082b52e4175c6d5f41eaa https://doi.org/10.1161/01.res.65.4.1102

View Full Paper

Ask AI

Bookmark

Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider