Key result
Muscle stimulation in rat gastrocnemius muscle resulted in an 11.3% drop in phosphocreatine levels within 16 ms, producing 3.1 mumol ATP/g tissue during a twitch.
Population
Rat gastrocnemius muscle
Comparison
Muscle stimulation/contraction vs Reference state (pre-contraction)
Design
Preclinical
Follow-up
16 ms after stimulation
Authors
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Animal twitch energetics data should not guide clinical practice; leaves open extension to human cardiac muscle.
The study demonstrates that a substantial energy fluctuation accompanies a muscle twitch, with ATP production significantly higher than previously derived from steady-state experiments.
Chung et al. (1998) studied this question. Muscle stimulation vs. reference state was evaluated on phosphocreatine (PCr) level. Muscle stimulation in rat gastrocnemius muscle resulted in an 11.3% drop in phosphocreatine levels within 16 ms, producing 3.1 mumol ATP/g tissue during a twitch.
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