Key result
In a postinfarction canine model, susceptibility to sudden cardiac death was associated with action potential prolongation and reductions in multiple repolarizing currents (P<0.05) compared to controls.
p-value: p=<0.05
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Should not change post-MI care; leaves open whether repolarizing current reductions drive SCD in humans.
Sridhar et al. (2008) studied Sudden cardiac death (post-myocardial infarction). Susceptibility to ventricular fibrillation (VF+) vs. VF(-) animals and noninfarcted controls was evaluated on Myocyte action potential prolongation and repolarizing currents (p=<0.05). In a postinfarction canine model, susceptibility to sudden cardiac death was associated with action potential prolongation and reductions in multiple repolarizing currents (P<0.05) compared to controls.
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