Key result
Ranolazine reduced the end-diastolic pressure-volume relationship slope and improved diastolic function during dobutamine challenge in spontaneously hypertensive rats.
Why the study?
Does ranolazine improve diastolic function in spontaneously hypertensive rats?
Does ranolazine improve diastolic function in spontaneously hypertensive rats?
Ranolazine improves diastolic function in spontaneously hypertensive rats by inhibiting late sodium current and reducing calcium overload.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating in hypertensive rats; human trials needed before considering ranolazine for diastolic dysfunction.
Williams et al. (2014) studied Diastolic dysfunction. Ranolazine vs. Vehicle was evaluated on Diastolic function and end-diastolic pressure-volume relationship slope. Ranolazine reduced the end-diastolic pressure-volume relationship slope and improved diastolic function during dobutamine challenge in spontaneously hypertensive rats.
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