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July 20, 2013AJP Heart and Circulatory PhysiologyOpen Access

Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat

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Why the study?

Does ranolazine prevent left ventricular hypertrophy and t-tubule disruption in a rat model of hypertensive heart disease?

Population

Male Spontaneously Hypertensive Rats, aged 7 months.

Comparison

Ranolazine 0.5% in chow for 3 months. vs Normal control chow for 3 months.

Design

Preclinical

Follow-up

3 months

Authors

GAGary L. AistrupDGDeepak K. GuptaJKJames E. Kelly

Discussion

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Overview

Hypothesis-generating for late Na current inhibition in hypertensive LVH models; human trials needed before clinical consideration.

Structured PICO

Does ranolazine prevent left ventricular hypertrophy and t-tubule disruption in a rat model of hypertensive heart disease?

P
Population
Male Spontaneously Hypertensive Rats (SHRs), aged 7 months (n=22 total; 16 for main study, 6 for ionic current measurements).
I
Intervention
Ranolazine 0.5% in chow for 3 months.
C
Comparator
Normal control chow for 3 months.
O
Outcome
Left ventricular hypertrophy (LV mass by echocardiography) and t-tubule organization/intracellular Ca2+ cycling using confocal microscopy.surrogate

Chronic inhibition of the late sodium current with ranolazine slows the progression of left ventricular hypertrophy and prevents ultrastructural and physiological calcium cycling defects in a rat model of hypertensive heart disease.

Cite This Study

Aistrup et al. (2013) studied this question.

synapsesocial.com/papers/6a7950e8bdf697b3de022e38https://doi.org/10.1152/ajpheart.00401.2013
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