Why the study?
Does selective ETA receptor blockade improve left ventricular and myocyte function in a rabbit model of pacing-induced congestive heart failure?
Population
36 rabbits undergoing chronic rapid ventricular pacing to induce congestive heart failure, or sham controls.
Comparison
Selective ETA receptor antagonist administered… vs RVP only (no ETA blockade) and sham controls.
Design
Preclinical
Follow-up
3 weeks
Authors
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ETA blockade attenuates LV dysfunction in rabbit pacing HF; hypothesis-generating for ET-1 role, with clinical translation untested.
Does selective ETA receptor blockade improve left ventricular and myocyte function in a rabbit model of pacing-induced congestive heart failure?
In a rabbit model of pacing-induced heart failure, chronic ETA receptor blockade improved left ventricular and myocyte function, suggesting a contributory role of ET-1 in heart failure progression.
Spinale et al. (1997) studied this question.
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