Why the study?
Does the selective ETA receptor blocker LU 135,252 prevent left ventricular remodeling and deterioration of cardiac function in a rat model of heart failure?
Population
Rat model of chronic heart failure (CHF) induced by coronary artery ligation
Comparison
Selective ETA receptor blocker LU 135,252 at a… vs Placebo
Design
Preclinical
Follow-up
10 weeks
Authors
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ETA blockade may attenuate remodeling in experimental HF; leaves open translation to human therapy.
Does the selective ETA receptor blocker LU 135,252 prevent left ventricular remodeling and deterioration of cardiac function in a rat model of heart failure?
Selective ETA receptor blockade with LU 135,252 prevents progressive left ventricular remodeling and improves cardiac hemodynamics in an experimental rat model of heart failure.
Paul Mulder (1998) studied this question.
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