Population
Isolated working rat heart mitochondria
Comparison
Perfusion with Sr2+ or Mn2+ replacing Ca2+ vs Ca2+-containing perfusate
Design
Preclinical
Authors
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No immediate clinical implications for Ca2+ handling; leaves open mitochondrial roles in human disease or other models.
Mitochondria play little if any role in the beat-to-beat regulation of normal Ca2+ fluxes in the rat heart.
Hunter et al. (1980) studied this question.
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