February 22, 1977Biochemistry

Transient phase of adenosine triphosphate hydrolysis by myosin, heavy meromyosin, and subfragment 1

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Population

Myosin, heavy meromyosin (HMM), and subfragment 1 (S-1) (in vitro biochemical model)

Design

Preclinical

Authors

ETEdwin W. TaylorOldham Council

Discussion

Member takes

Implication

Supports symmetric myosin hydrolysis in vitro; leaves open applicability to cardiac sarcomere function in vivo.

Structured PICO

Population

Myosin, heavy meromyosin (HMM), and subfragment 1 (S-1) (in vitro biochemical model)

Intervention

Varying temperatures and pH levels

Outcome

Transient phase of ATP hydrolysis (early burst size and rate)surrogate

This basic science study demonstrates that both myosin heads undergo rapid ATP hydrolysis, with no significant differences between subfragment 1, heavy meromyosin, or intact myosin.

Cite This Study

Edwin W. Taylor (1977) studied this question.

synapsesocial.com/papers/6a20a8389ca8a48788f36f47 https://doi.org/10.1021/bi00623a027

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Transient phase of adenosine triphosphate hydrolysis by myosin, heavy meromyosin, and subfragment 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transient phase of adenosine triphosphate hydrolysis by myosin, heavy meromyosin, and subfragment 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider