Population
Heavy meromyosin, a proteolytic subfragment of myosin, isolated from rabbit skeletal muscle
Design
Preclinical
Authors
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No immediate clinical implications for cardiovascular care; leaves open mechanistic studies of myosin kinetics in cardiac muscle.
The H+ initial burst during ATP hydrolysis by heavy meromyosin likely represents a fast ionization of H+ due to a conformational change resulting from nucleotide binding.
Chock et al. (1974) studied this question.
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