November 1, 1967CirculationOpen Access

Effect of Artificial Pacing of the Heart on Cardiac and Renal Function

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Why the study?

Does artificial pacing to increase heart rate improve renal and cardiac function in patients with complete heart block?

Population

6 patients with complete heart block

Comparison

Artificial pacemaker increasing heart rate to… vs Baseline state

Design

Case_series

Follow-up

7 to 8 months

Authors

JHJ. O’Neal HumphriesMIT University EHEdward John HinmanJohns Hopkins University LBL. BernsteinUniversity of Southern California

Discussion

Member takes

Implication

May support long-term pacing evaluation for renal effects in complete heart block; hypothesis-generating and requires prospective trials.

Structured PICO

Does artificial pacing to increase heart rate improve renal and cardiac function in patients with complete heart block?

Population

6 patients with complete heart block

Intervention

Artificial pacemaker increasing heart rate to 70/min (acute and long-term pacing for 7 to 8 months)

Comparator

Baseline state (idioventricular rhythm and slow rates at rest and following exercise)

Outcome

Renal hemodynamic responses (glomerular filtration rate, ability to excrete a water load/solute-free water)surrogate

Long-term artificial pacing in patients with complete heart block improves renal hemodynamics, specifically glomerular filtration rate and free water excretion.

Cite This Study

Humphries et al. (1967) studied this question.

synapsesocial.com/papers/6a20ba22e19207255aa024ec https://doi.org/10.1161/01.cir.36.5.717

Topics

Heart failure HFrEF treatment

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Effect of Artificial Pacing of the Heart on Cardiac and Renal Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effect of Artificial Pacing of the Heart on Cardiac and Renal Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider