Key result
Pre-interventional TIMI flow grade 0 in patients with STEMI was associated with a significantly higher risk of major adverse cardiac events at 1 year compared to TIMI flow grade I-III (OR 6.337).
Why the study?
The prognostic role of spontaneous recanalization in STEMI patients remains unclear.
Does pre-procedural TIMI flow grade I-III improve clinical outcomes compared to TIMI flow grade 0 in patients with STEMI treated by primary PCI?
Population
150 Egyptian STEMI patients presenting within 24 h from chest pain onset treated with primary PCI
Comparison
Initial TIMI flow grade 0 vs initial TIMI flow grade I-III in the infarct related artery
Design
Dual center prospective observational study
Follow-up
1 year
Authors
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May inform risk stratification by pre-PCI TIMI flow in STEMI; leaves open whether interventions targeting flow improve outcomes.
Cohort (n=150)
Yes
Does pre-procedural TIMI flow grade I-III improve clinical outcomes compared to TIMI flow grade 0 in patients with STEMI treated by primary PCI?
Odds Ratio: 6.337 (95% CI 1.566–25.642)
Absolute Event Rate: 28% vs 5.3%
p-value: p=0.010
In patients with STEMI undergoing primary PCI, spontaneous recanalization (pre-procedural TIMI flow I-III) is associated with significantly lower in-hospital and 1-year mortality compared to absent flow (TIMI 0).
Shaaban et al. (2022) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=150). Pre-interventional TIMI flow grade 0 vs. Pre-interventional TIMI flow grade I-III was evaluated on Major adverse cardiac events (MACE) at 1 year (OR 6.337, 95% CI 1.566-25.642, p=0.010). Pre-interventional TIMI flow grade 0 in patients with STEMI was associated with a significantly higher risk of major adverse cardiac events at 1 year compared to TIMI flow grade I-III (OR 6.337).
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