Key result
Long-term swimming increased the gene expression of VEGF-B, Angiopoietin 1&2, and MMP-2 compared to control and mid-term groups, while FGF-B expression increased only in the mid-term group.
Why the study?
A relationship between angiogenesis and oxidative stress had been reported in previous studies, prompting comparison of mid-term and long-term exercise protocols on left ventricular angiogenesis.
Does mid-term and long-term swimming improve left ventricular angiogenesis in male rats?
RCT (n=18)
Randomly assigned
No
Does mid-term and long-term swimming improve left ventricular angiogenesis in male rats?
Long-term swimming induces left ventricular angiogenesis likely via shear stress (increased NO), whereas mid-term swimming induces it via oxidative stress (increased MDA).
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for duration-dependent LV angiogenesis in rats; human studies needed before any clinical relevance.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Ardakanizadeh et al. (2021) conducted an RCT in Healthy (n=18). Mid and long-term swimming vs. Control (no swimming) was evaluated on Gene expression of Vascular-endothelial-growth-factor-B, Fibroblast-Growth-Factor-B, Angiopoiteine 1&2, and Matrix-metalloproteinases-2 (p=0.001). Long-term swimming increased the gene expression of VEGF-B, Angiopoietin 1&2, and MMP-2 compared to control and mid-term groups, while FGF-B expression increased only in the mid-term group.
Synapse has enriched 10 related papers. Consider them for comparative context: